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Conf Proc IEEE Eng Med Biol Soc. 2010;2010:2682-5. doi: 10.1109/IEMBS.2010.5626632.

Corticostriatal dynamics during learning and performance of a neuroprosthetic task.

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Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA.


Corticostriatal dynamics exhibit gross alterations over the course of natural motor learning, yet little is known about the role they play in neuroprosthetic tasks. We therefore investigated interactions between the striatum and primary motor cortex while rats learned to control a brain-machine interface. Striatal firing rates increased greatly from early to late in learning, suggesting that the striatum underlies similar functions in both natural and neuroprosthetic motor learning. In addition, spike-field coherence between neurons in primary motor cortex and local field potentials in the striatum increased greatly in the alpha band in late learning relative to early learning, suggesting the development of functional interactions in corticostriatal networks over the course of learning.

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