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Biochem Biophys Res Commun. 2011 Jan 7;404(1):103-8. doi: 10.1016/j.bbrc.2010.11.075. Epub 2010 Nov 21.

Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion.

Author information

1
Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.

Abstract

Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.

PMID:
21095181
DOI:
10.1016/j.bbrc.2010.11.075
[Indexed for MEDLINE]

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