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Bioorg Med Chem Lett. 2011 Jan 1;21(1):259-61. doi: 10.1016/j.bmcl.2010.11.017. Epub 2010 Nov 5.

A new and efficient synthetic route for the anxiolytic agent CL285032.

Author information

1
Moulder Center for Drug Discovery Research, Temple University School of Pharmacy, 3307 N Broad Street, Philadelphia, PA 19140, USA.

Abstract

CL285032 is an anxiolytic compound currently under investigation as a possible treatment for canine noise phobia associated anxiety. A robust scale-up and manufacturing process is essential for the development and marketability of the drug. The current synthetic route, although reliable, requires seven steps and has a low overall yield (18%), leaving opportunity for improvement. We are presenting an efficient alternative approach toward the synthesis of CL285032 and the results thereof.

PMID:
21095124
DOI:
10.1016/j.bmcl.2010.11.017
[Indexed for MEDLINE]

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