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Transplant Proc. 2010 Nov;42(9):3399-405. doi: 10.1016/j.transproceed.2010.06.013.

Stem cell factor, interleukin-16, and interleukin-2 receptor alpha are predictive biomarkers for delayed and slow graft function.

Author information

1
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. nalachk1@jhmi.edu

Abstract

INTRODUCTION:

Delayed graft function (DGF) and slow graft function (SGF) due to ischemic and reperfusion injury (IRI) are common complications of deceased donor kidney transplantation. We tested whether a panel of serum and urine cytokines represent early biomarkers for DGF and SGF.

METHODS:

We collected serum and urine samples from 61 patients 48 hours posttransplantation and used a multiplex enzyme-linked immunosorbent assay (ELISA) technique to measure levels of 23 cytokines. Fourteen patients developed poor graft function (PGF), with 6 having DGF and 8 with SGF.

RESULTS:

Area under receiver operation characteristics curve (AUC) demonstrated the following: serum levels of SCF (0.88) and interleukin (IL) 16 (0.74).

CONCLUSIONS:

This study showed that a select panel of cytokines measured early post kidney transplantation may predict poor graft function.

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