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Plasmid. 2011 Mar;65(2):77-101. doi: 10.1016/j.plasmid.2010.11.005. Epub 2010 Nov 19.

The information transfer system of halophilic archaea.

Author information

1
Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.

Abstract

Information transfer is fundamental to all life forms. In the third domain of life, the archaea, many of the genes functioning in these processes are similar to their eukaryotic counterparts, including DNA replication and repair, basal transcription, and translation genes, while many transcriptional regulators and the overall genome structure are more bacterial-like. Among halophilic (salt-loving) archaea, the genomes commonly include extrachromosomal elements, many of which are large megaplasmids or minichromosomes. With the sequencing of genomes representing ten different genera of halophilic archaea and the availability of genetic systems in two diverse models, Halobacterium sp. NRC-1 and Haloferax volcanii, a large number of genes have now been annotated, classified, and studied. Here, we review the comparative genomic, genetic, and biochemical work primarily aimed at the information transfer system of halophilic archaea, highlighting gene conservation and differences in the chromosomes and the large extrachromosomal elements among these organisms.

PMID:
21094181
DOI:
10.1016/j.plasmid.2010.11.005
[Indexed for MEDLINE]

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