Format

Send to

Choose Destination
Thromb Res. 2011 Apr;127(4):287-91. doi: 10.1016/j.thromres.2010.10.012. Epub 2010 Nov 19.

Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes.

Author information

1
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY 14642,USA. majed_refaai@urmc.rochester.edu

Abstract

Platelet transfusion is one of the most crucial therapeutic approaches in Medicine. However, severe and fatal adverse reactions may develop. In addition to their important function in hemostasis, platelets' role in inflammation has become more evident. Recently, platelets are also recognized as the main source of circulating soluble CD40 ligand (sCD40L, (CD154)), which plays significant roles in hemostasis, platelet activation, clot stability, interactions with other cells, and upregulation of different mediators. In this review, we will briefly highlight the importance of platelet transfusion, its role in inflammatory and thrombotic transfusion reactions, and visit the most recent findings on sCD40L.

PMID:
21093892
PMCID:
PMC3062691
DOI:
10.1016/j.thromres.2010.10.012
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center