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Bioorg Med Chem. 2011 Jan 1;19(1):650-62. doi: 10.1016/j.bmc.2010.10.033. Epub 2010 Oct 20.

Identification of 3-sulfonylindazole derivatives as potent and selective 5-HT(6) antagonists.

Author information

1
Chemical Sciences, Wyeth Research, CN 8000, Princeton, NJ 08543, USA. liuk@lundbeck.com

Abstract

As part of our efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT(6) receptor in order to identify potent and selective ligands for this purpose. Herein we report the identification of a novel series of 3-sulfonylindazole derivatives with acyclic amino side chains as potent and selective 5-HT(6) antagonists. The synthesis and detailed SAR of this class of compounds are reported.

PMID:
21093272
DOI:
10.1016/j.bmc.2010.10.033
[Indexed for MEDLINE]

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