Heart rate dynamics in temporal lobe epilepsy-A long-term follow-up study

Eija Suorsa; Juha T Korpelainen; Hanna Ansakorpi; Heikki V Huikuri; Ville Suorsa; Vilho V Myllylä; Jouko I T Isojärvi

doi:10.1016/j.eplepsyres.2010.10.005

Heart rate dynamics in temporal lobe epilepsy-A long-term follow-up study

Epilepsy Res. 2011 Jan;93(1):80-3. doi: 10.1016/j.eplepsyres.2010.10.005. Epub 2010 Nov 18.

Authors

Eija Suorsa¹, Juha T Korpelainen, Hanna Ansakorpi, Heikki V Huikuri, Ville Suorsa, Vilho V Myllylä, Jouko I T Isojärvi

Affiliation

¹ Department of Neurology, University of Oulu, Oulu, Finland. eronkain@paju.oulu.fi

PMID: 21093218
DOI: 10.1016/j.eplepsyres.2010.10.005

Abstract

The aim of the present study was to prospectively evaluate long-term changes in interictal heart rate variability (HRV) in patients with temporal lobe epilepsy (TLE). A 24-h ECG was recorded at baseline and after a mean follow-up of 6.1 years in 18 patients with refractory TLE and 18 patients with well-controlled TLE. After the follow-up, the Poincaré components SD(1) (p=0.039) and SD(2) (p=0.001) were decreased in patients with refractory TLE compared to baseline, whereas in patients with well-controlled TLE no changes (p>0.05) in HR variability were observed. The reduction in HRV seems to be progressive in patients with chronic refractory TLE with recurrent seizures.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anticonvulsants / therapeutic use
Electrocardiography / methods
Electroencephalography / methods
Epilepsy, Temporal Lobe / drug therapy
Epilepsy, Temporal Lobe / physiopathology*
Female
Heart Rate / drug effects
Heart Rate / physiology*
Humans
Longitudinal Studies
Male
Nonlinear Dynamics*
Statistics, Nonparametric

Substances

Anticonvulsants