Format

Send to

Choose Destination
See comment in PubMed Commons below
Ann N Y Acad Sci. 2011 Jan;1217:83-95. doi: 10.1111/j.1749-6632.2010.05826.x. Epub 2010 Nov 22.

Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation.

Author information

1
Department of Pediatrics, Children's Hospital of Philadelphia Research Institute, University of Pennsylvania Medical School, Philadelphia, Pennsylvania, USA. DOUGLAS@email.chop.edu

Abstract

The G protein-coupled receptor (GPCR), neurokinin-1 receptor (NK1R), and its preferred ligand, substance P (SP), are reviewed in relationship to the immune system and selected infections. NK1R and SP are ubiquitous throughout the animal kingdom. This important pathway has unique functions in numerous cells and tissues. The interaction of SP with its preferred receptor, NK1R, leads to the activation of nuclear factor-kappa B (NF-κB) and proinflammatory cytokines. NK1R has two isoforms, both a full-length and a truncated form. These isoforms have different functional significances and differ in cell signaling capability. The proinflammatory signals modulated by SP are important in bacterial, viral, fungal, and parasitic diseases, as well as in immune system function. The SP-NK1R system is a major class 1, rhodopsin-like GPCR ligand-receptor interaction.

PMID:
21091716
PMCID:
PMC3058850
DOI:
10.1111/j.1749-6632.2010.05826.x
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Support Center