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Br J Pharmacol. 2011 Mar;162(6):1225-38. doi: 10.1111/j.1476-5381.2010.01118.x.

Sphingosine-1-phosphate antibodies as potential agents in the treatment of cancer and age-related macular degeneration.

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1
Lpath, Inc., 6335 Ferris Square, Suite A, San Diego, CA 92121, USA. rsabbadini@lpath.com

Abstract

Sphingosine-1-phosphate (S1P) is a pleiotropic bioactive lipid thought to be dysregulated in a variety of disease conditions. In this review, we discuss the roles of S1P in cancer and in wet age-related macular degeneration. We also explore potential treatment strategies for these disorders, including the utility of anti-S1P antibodies acting as molecular sponges to neutralize dysregulated S1P in relevant tissues.

PMID:
21091645
PMCID:
PMC3058156
DOI:
10.1111/j.1476-5381.2010.01118.x
[Indexed for MEDLINE]
Free PMC Article
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