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Clin Exp Hypertens. 2010;32(8):491-8. doi: 10.3109/10641961003686427.

Long-term effects of Xuezhikang on blood pressure in hypertensive patients with previous myocardial infarction: data from the Chinese Coronary Secondary Prevention Study (CCSPS).

Collaborators (209)

Xu YS, Gu DF, Jia X, Chen Z, Sun JL, Chen J, Yu XH, Wang JH, Wang N, Zheng RP, Zhang SH, Liu CX, Sun LH, Zhao YC, Lin Y, Huang JB, Hu DY, Yang XC, Liu YZ, Gao MM, Zhang P, Deng CX, Liu Y, Li ZQ, Shi YQ, Hu TS, Chen YZ, Tan S, Zhao WR, Deng GL, Huang WJ, Zhang JC, Yu H, Shi QS, Wang XZ, Jiang B, Pan XR, Li L, Bu PL, Shu MQ, Xu QL, Zhang JH, Ding WH, Li L, Yang JJ, Su JL, Zhao WD, Liu X, Li LJ, Yang JF, Wang QS, Huang TG, Li LF, Zhou LJ, Guo JX, Li WH, Li ZP, Zhang XG, Peng XM, An YW, Shu J, Ma LT, Ge H, Zhang MJ, Lv ZR, Li JH, Yang JW, Zhang L, Cheng YL, Chen JG, Zhou CW, Zhang HH, Huang YL, Qu XF, Li JJ, Guo H, Wang GX, Hao SZ, Li SJ, Chang HS, Zhou SM, Liang HQ, Cao SJ, Liu JG, Yang J, Zhao MY, Lv Y, Xu SL, Wang ZL, Zhao SP, Li XP, Luo XL, Li YP, Lei Y, Fan SQ, Wang LH, Zhao LJ, Zhao YC, Xue SW, Li J, Xu SY, Cao YG, Tong BG, Wang W, Xu SK, Chen HZ, Guo WL, Wang LJ, Yan XM, Li Y, Wei LP, Qiao L, Gao SS, Jing XF, Wang CH, Tang BX, Bai H, Li L, Liu Y, Li YP, Mei F, Yuan KZ, Zhang Y, Sun YR, Chen L, Xue SR, Wang JP, Li B, Liu ZM, Shen LH, Liang JR, Zhang Y, Song YL, Sun YM, Wan Z, Xu YH, Zhang WJ, Mu RQ, Li KQ, Wei YP, Wang SM, Fan YJ, An KY, Guo J, Li AP, Zeng DY, Huo HY, Chen Y, Song LX, Jiang BQ, Guo DJ, Chen H, Li L, Yin YQ, Mao YM, Miao L, Guo YJ, Li SJ, Cui SS, Diao Q, You XM, Jiang B, Zhu LT, Liu JM, Fang L, Lin SG, Chen LY, Huang WH, Zheng ZG, Ke YN, Wang Y, Wang QS, Liang H, Jia RY, Wang T, Liu CX, Geng QJ, Duan BX, Fang CQ, Wang JY, Chang ZW, Qi Y, Wang X, He WS, Ye P, Liu YC, Li CY, Ye JJ, He BX, Zhang XY, Hong XF, Shi RG, Wei WL, Sun JJ, Li ZC, Zhang XJ, He P, Gao W, He YJ, Zhang HB, Li ND, He XN, Chen GL, Wang JL, Liang GF, Dai GZ, Wang Q, Jin HY, Wang S.

Author information

Department of Cardiology, Fu Wai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, PR China.


Several previous trials from Western population studies have showed that statins may help reduce blood pressure (BP). However, randomized clinical data is limited. Xuezhikang, a partially extract of red yeast rice, contains a family of naturally occurring statins, and has a marked impact on lipids, but it is unknown whether Xuezhikang has any effect on BP during long-term follow-up in the Chinese population. This is a post-hoc subgroup analysis of a randomized, double-blinded, placebo-controlled, parallel group clinical trial, Chinese Coronary Secondary Prevention Study (CCSPS). A total of 2704 hypertensive patients with previous myocardial infarction (MI) were assigned either to placebo (n = 1341) or to Xuezhikang (n = 1363) daily for an average of 4.5 years. The primary outcome was the unadjusted changes in mean arterial pressure (MAP) from baseline to 6 months. We also assessed systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse pressure. Analysis of covariance was used to calculate the adjusted effects of treatment on changes in these outcomes at 6, 12, 24, and 48 months post-randomization, after controlling for potential confounders. This analysis included 2704/4870 (55.5%) hypertensive patients for whom BP was measured at baseline and at least one follow-up visit after randomization. Median duration of the follow-up was 4.5 years (54 months), and 25 patients (0.92%) were lost to the last follow-up because of adverse effects. The results showed that the unadjusted and adjusted changes in MAP, SBP, DBP, or pulse pressure from baseline were not significantly different for Xuezhikang or placebo recipients at 6, 12, 24, and 48 months after randomization. In this post-hoc subgroup analysis, we failed to demonstrate any significant reducing effects of Xuezhikang on BP in Chinese hypertensive patients with previous MI, suggesting that further prospective study on the effects of statins on BP would be needed, especially in high-risk patients.

[Indexed for MEDLINE]

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