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Nat Rev Immunol. 2010 Dec;10(12):826-37. doi: 10.1038/nri2873. Epub 2010 Nov 19.

Sterile inflammation: sensing and reacting to damage.

Author information

1
Department of Internal Medicine, Comprehensive Cancer Center, University of Michigan, Michigan 48109, USA. gchenry@umich.edu

Abstract

Over the past several decades, much has been revealed about the nature of the host innate immune response to microorganisms, with the identification of pattern recognition receptors (PRRs) and pathogen-associated molecular patterns, which are the conserved microbial motifs sensed by these receptors. It is now apparent that these same PRRs can also be activated by non-microbial signals, many of which are considered as damage-associated molecular patterns. The sterile inflammation that ensues either resolves the initial insult or leads to disease. Here, we review the triggers and receptor pathways that result in sterile inflammation and its impact on human health.

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PMID:
21088683
PMCID:
PMC3114424
DOI:
10.1038/nri2873
[Indexed for MEDLINE]
Free PMC Article

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