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Exerc Sport Sci Rev. 2011 Jan;39(1):34-42. doi: 10.1097/JES.0b013e318201f236.

Heat shock proteins are important mediators of skeletal muscle insulin sensitivity.

Author information

1
University of Kansas Medical Center, Department of Molecular and Integrative Physiology, Kansas City, KS 66160, USA. pgeiger@kumc.edu

Abstract

Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.

PMID:
21088604
PMCID:
PMC3670665
DOI:
10.1097/JES.0b013e318201f236
[Indexed for MEDLINE]
Free PMC Article

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