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Chemotherapy. 2010;56(6):448-52. doi: 10.1159/000320943. Epub 2010 Nov 18.

Resistance status and evolution trends of Klebsiella pneumoniae isolates in a university hospital in Greece: ineffectiveness of carbapenems and increasing resistance to colistin.

Author information

1
Department of Clinical Bacteriology, Parasitology, Zoonoses and Geographical Medicine, University Hospital of Heraklion, Heraklion, Greece. ineonakis@gmail.com

Abstract

BACKGROUND:

Due to its increased non-susceptibility rates, Klebsiella pneumoniae has emerged as one of the most problematic pathogens.

METHODS:

The level of resistance to 25 antimicrobials of K. pneumoniae isolates from a teaching hospital in Greece and the evolution trends during 2 decades were examined.

RESULTS:

A statistically significant increase in non-susceptibility rates was found for almost all antimicrobials examined. During 2008, the isolates presented non-susceptibility rates to aminoglycosides >50% and to quinolones >60%. Nowadays, 1 out of 10 isolates is non-susceptible to colistin. Moreover, the isolates non-susceptible to imipenem were almost doubled between 2007 (29%) and 2008 (50%). Among the imipenem-resistant isolates, 1 out of 4 was also resistant to colistin.

CONCLUSION:

The effectiveness of carbapenems has been compromised and the increase in resistance to colistin is rapid and steep.

PMID:
21088396
DOI:
10.1159/000320943
[Indexed for MEDLINE]

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