Format

Send to

Choose Destination
Ann Nutr Metab. 2010;57(3-4):177-82. doi: 10.1159/000321538. Epub 2010 Nov 17.

Effect of antioxidant vitamins on the plasma homocysteine level in a free-living elderly population.

Author information

1
Institutes of Nutritional Science, Justus Liebig University, Giessen, Germany.

Abstract

BACKGROUND:

The factors influencing total plasma homocysteine levels (tHcy) are of special interest in the attempt to reduce cardiovascular risk.

AIM:

This investigation aimed to assess the independent effects of antioxidant vitamins on tHcy in elderly people.

METHODS:

Our cross-sectional analysis included data of 184 subjects (≥60 years) from the longitudinal study in an aging population in Giessen (GISELA), Germany. We examined the effects of plasma levels, intake and supplementation of vitamin C, vitamin E, and β-carotene on tHcy.

RESULTS:

The mean tHcy was within the normal range in this population. Serum folate, the estimated glomerular filtration rate (eGFR), and plasma vitamin C showed a negative association with tHcy in simple regression analysis. In a subsequent multiple regression analysis, eGFR, serum folate, and plasma vitamin C were the relevant independent predictors of tHcy. Intake and supplementation of vitamin C, as well as plasma levels, intake and supplementation of vitamin E, and β-carotene were not associated with tHcy.

CONCLUSION:

Vitamin C may be an independent predictor of tHcy in free-living elderly people and, therefore, should be considered in attempts to reduce tHcy.

PMID:
21088383
DOI:
10.1159/000321538
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for S. Karger AG, Basel, Switzerland
Loading ...
Support Center