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Am J Clin Pathol. 2010 Dec;134(6):873-9. doi: 10.1309/AJCPPPR57HNJMSLZ.

Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade.

Author information

1
Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA.

Abstract

Carbonic anhydrase IX (CAIX), a hypoxia-induced protein, is expressed in some renal tumors. We evaluated its immunohistochemical expression in 317 primary and 42 metastatic renal neoplasms (186 clear cell, 52 papillary, 35 chromophobe, 47 unclassified, and 15 Xp11.2 translocation renal cell carcinomas [RCCs]; 26 oncocytomas; 2 metanephric adenomas; 1 urothelial carcinoma; 1 mixed epithelial and stromal tumor; and 1 angiomyolipoma); 7 neoplasms were unknown as to whether they were primary or metastatic. We also correlated expression with tumor type and grade. Variable staining was seen in clear cell, papillary, unclassified, and Xp11.2 translocation carcinomas. One chromophobe carcinoma had focal expression. No staining was seen with other tumors. An association was found between high expression and clear cell vs non-clear cell carcinomas with all cases (P < .01) and primary (P < .01) cases. An association between CAIX expression and grade (P < .01) in primary clear cell carcinomas was found. CAIX expression is more common in clear cell RCC than other renal tumor types and is associated with grade.

PMID:
21088149
PMCID:
PMC3778911
DOI:
10.1309/AJCPPPR57HNJMSLZ
[Indexed for MEDLINE]
Free PMC Article

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