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Trends Mol Med. 2010 Dec;16(12):553-60. doi: 10.1016/j.molmed.2010.10.006. Epub 2010 Nov 17.

Nanotechnology for synthetic high-density lipoproteins.

Author information

1
Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA.

Abstract

Atherosclerosis is the disease mechanism responsible for coronary heart disease (CHD), the leading cause of death worldwide. One strategy to combat atherosclerosis is to increase the amount of circulating high-density lipoproteins (HDL), which transport cholesterol from peripheral tissues to the liver for excretion. The process, known as reverse cholesterol transport, is thought to be one of the main reasons for the significant inverse correlation observed between HDL blood levels and the development of CHD. This article highlights the most common strategies for treating atherosclerosis using HDL. We further detail potential treatment opportunities that utilize nanotechnology to increase the amount of HDL in circulation. The synthesis of biomimetic HDL nanostructures that replicate the chemical and physical properties of natural HDL provides novel materials for investigating the structure-function relationships of HDL and for potential new therapeutics to combat CHD.

PMID:
21087901
PMCID:
PMC4076051
DOI:
10.1016/j.molmed.2010.10.006
[Indexed for MEDLINE]
Free PMC Article

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