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Vaccine. 2011 Jan 10;29(3):399-411. doi: 10.1016/j.vaccine.2010.11.007. Epub 2010 Nov 16.

The use of immunization registry-based data in vaccine effectiveness studies.

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Clinical and Population Health Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655-0002, USA.


Vaccine effectiveness (VE) studies provide a measure of population-based vaccine performance by combining immunization history data with rates of disease incidence. This review assessed the feasibility of using electronic immunization registry data sources in VE studies. Electronic databases were searched through January 31, 2010. Out of 17 studies, only one paper assessed data accuracy (71%), and three papers assessed population coverage of the registry (estimates ranged from 25% to 90%). This review shows that registry-based data sources can be used to conduct VE studies in a variety of settings and populations. However, we found little information regarding the quality of this data source in VE studies and future evaluations should investigate their reliability, accuracy, and potential bias.

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