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Chromosome Res. 2010 Dec;18(8):909-24. doi: 10.1007/s10577-010-9169-0. Epub 2010 Nov 18.

Many functions of the meiotic cohesin.

Author information

1
amitbardhan@gmail.com

Abstract

Sister chromatids are held together from the time of their formation in S phase until they segregate in anaphase by the cohesin complex. In meiosis of most organisms, the mitotic Mcd1/Scc1/Rad21 subunit of the cohesin complex is largely replaced by its paralog named Rec8. This article reviews the specialized functions of Rec8 that are crucial for diverse aspects of chromosome dynamics in meiosis, and presents some speculations relating to meiotic chromosome organization.

PMID:
21086039
DOI:
10.1007/s10577-010-9169-0
[Indexed for MEDLINE]

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