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PLoS One. 2010 Nov 10;5(11):e15402. doi: 10.1371/journal.pone.0015402.

Angiogenin levels and ANG genotypes: dysregulation in amyotrophic lateral sclerosis.

Author information

1
Smurfit Institute of Genetics, Trinity College Dublin, Dublin, Ireland. mclaugr@tcd.ie

Abstract

OBJECTIVE:

To determine whether 5 single nucleotide polymorphisms (SNPs) associate with ALS in 3 different populations. We also assessed the contribution of genotype to angiogenin levels in plasma and CSF.

METHODS:

Allelic association statistics were calculated for polymorphisms in the ANG gene in 859 patients and 1047 controls from Sweden, Ireland and Poland. Plasma, serum and CSF angiogenin levels were quantified and stratified according to genotypes across the ANG gene. The contribution of SNP genotypes to variance in circulating angiogenin levels was estimated in patients and controls.

RESULTS:

All SNPs showed association with ALS in the Irish group. The SNP rs17114699 replicated in the Swedish cohort. No SNP associated in the Polish cohort. Age- and sex-corrected circulating angiogenin levels were significantly lower in patients than in controls (p<0.001). An allele dose-dependent regulation of angiogenin levels was observed in controls. This regulation was attenuated in the ALS cohort. A significant positive correlation between CSF plasma angiogenin levels was present in controls and abolished in ALS.

CONCLUSIONS:

ANG variants associate with ALS in the Irish and Swedish populations, but not in the Polish. There is evidence of dysregulation of angiogenin expression in plasma and CSF in sporadic ALS. Angiogenin expression is likely to be important in the pathogenesis of ALS.

PMID:
21085671
PMCID:
PMC2978104
DOI:
10.1371/journal.pone.0015402
[Indexed for MEDLINE]
Free PMC Article
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