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Nat Rev Genet. 2010 Dec;11(12):855-66. doi: 10.1038/nrg2897.

Phenomics: the next challenge.

Author information

1
Department of Biological Science, Florida State University, Tallahassee, 32306-4295, USA. dhoule@bio.fsu.edu

Abstract

A key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and environment, and such a 'genotype-phenotype' map is inaccessible without the detailed phenotypic data that allow these interactions to be studied. Despite this need, our ability to characterize phenomes - the full set of phenotypes of an individual - lags behind our ability to characterize genomes. Phenomics should be recognized and pursued as an independent discipline to enable the development and adoption of high-throughput and high-dimensional phenotyping.

PMID:
21085204
DOI:
10.1038/nrg2897
[Indexed for MEDLINE]

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