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J Comput Assist Tomogr. 2010 Nov-Dec;34(6):933-8. doi: 10.1097/RCT.0b013e3181ef9fbe.

Repeated low-dose computed tomography in current and former smokers for quantification of emphysema.

Author information

1
Department of Medical Imaging, University Health Network, Toronto, Ontario, Canada.

Abstract

OBJECTIVE:

To quantify different emphysema evolution in current and former smokers.

METHODS:

We retrospectively analyzed low-dose computed tomography scans from a lung cancer screening study of 59 current and 75 former smokers. The quantitative emphysema analysis was performed using a home-built software (YACTA version 0.9), yielding the parameters lung volume, emphysema volume (EV), emphysema index (EI), mean lung density, and 15th percentile.

RESULTS:

The baseline EV and EI were significantly different (median EVformer =422 mL vs EVcurrent =249 mL, P = 0.0003; and median EIformer =7.6 % vs EIcurrent =4.1 %, P = 0.0001, respectively). On the annual repeat scan, the median EI and EV for former smokers had decreased significantly (ΔEIformer = -0.257%, P = 0.004; and ΔEVcurrent = -0.203 mL, P = 0.020), whereas there was no emphysema change in current smokers.

CONCLUSIONS:

We were able to demonstrate different emphysema evolution in current versus former smokers; emphysema parameters decreased in the former smokers and remained stable in current smokers.

PMID:
21084912
DOI:
10.1097/RCT.0b013e3181ef9fbe
[Indexed for MEDLINE]
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