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J Immunol. 2010 Dec 1;185(11):6413-9. doi: 10.4049/jimmunol.1001829.

The role of the transcription factor CREB in immune function.

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1
Division of Pediatric Critical Care, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.

Abstract

CREB is a transcription factor that regulates diverse cellular responses, including proliferation, survival, and differentiation. CREB is induced by a variety of growth factors and inflammatory signals and subsequently mediates the transcription of genes containing a cAMP-responsive element. Several immune-related genes possess this cAMP-responsive element, including IL-2, IL-6, IL-10, and TNF-α. In addition, phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-κB complex, thereby limiting proinflammatory responses. CREB also induces an antiapoptotic survival signal in monocytes and macrophages. In T and B cells, CREB activation promotes proliferation and survival and differentially regulates Th1, Th2, and Th17 responses. Finally, CREB activation is required for the generation and maintenance of regulatory T cells. This review summarizes current advances involving CREB in immune function--a role that is continually being defined.

PMID:
21084670
DOI:
10.4049/jimmunol.1001829
[Indexed for MEDLINE]
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