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Cancer Inform. 2010 Nov 1;9:257-64. doi: 10.4137/CIN.S5755.

Cross-platform Comparison of Two Pancreatic Cancer Phenotypes.

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Departments of Oncology.

Abstract

Model-based approaches for combining gene expression data from multiple high throughput platforms can be sensitive to technological artifacts when the number of samples in each platform is small. This paper proposes simple tools for quantifying concordance in a small study of pancreatic cancer cells lines with an emphasis on visualizations that uncover intra- and inter-platform variation. Using this approach, we identify several transcripts from the integrative analysis whose over-or under-expression in pancreatic cancer cell lines was validated by qPCR.

KEYWORDS:

cross-platform; differential gene expression; microarrays; rank statistics

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