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Sci Signal. 2010 Nov 16;3(148):pe43. doi: 10.1126/scisignal.3148pe43.

Frizzled signaling: Gαo and Rab5 at the crossroads of the canonical and PCP pathways?

Author information

1
Medical Research Council (MRC) Centre for Developmental and Biomedical Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, UK.

Abstract

Endocytosis modulates the activities of members of a family of receptors known as Frizzled (Fz) proteins, which control canonical β-catenin signaling and the planar cell polarity pathway; however, what determines which of the two pathways is activated is unclear. Evidence now suggests that the guanosine triphosphatase Rab5, a key regulator of endocytosis, binds directly to Fz proteins and that subsequent trafficking steps determine the outcome of Fz signaling.

PMID:
21081753
DOI:
10.1126/scisignal.3148pe43
[Indexed for MEDLINE]

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