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Cell. 1990 Apr 6;61(1):19-26.

C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus.

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Department of Biochemistry, Stanford University School of Medicine, California 94305.


During fruiting body development, the product of the csgA gene is necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hr of starvation. From nascent wild-type fruiting bodies we have purified a polypeptide of 17 kd called C-factor, which, at approximately 1 to 2 nM, restores normal development to csgA mutant cells. C-factor activity is not recovered from extracts of unstarved, growing cells or csgA mutant cells. The amino acid sequence from purified C-factor demonstrates that it is the product of the csgA gene. C-factor is active over a narrow range of concentration and has properties of a morphogenetic paracrine signal.

[Indexed for MEDLINE]

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