Format

Send to

Choose Destination
Mol Psychiatry. 2011 Mar;16(3):342-52. doi: 10.1038/mp.2010.116. Epub 2010 Nov 16.

Touch gives new life: mechanosensation modulates spinal cord adult neurogenesis.

Author information

1
Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel.

Erratum in

  • Mol Psychiatry. 2012 Apr;17(4):469. Rolls A [added].

Abstract

The ability to respond to a wide range of novel touch sensations and to habituate upon repeated exposures is fundamental for effective sensation. In this study we identified adult spinal cord neurogenesis as a potential novel player in the mechanism of tactile sensation. We demonstrate that a single exposure to a novel mechanosensory stimulus induced immediate proliferation of progenitor cells in the spinal dorsal horn, whereas repeated exposures to the same stimulus induced neuronal differentiation and survival. Most of the newly formed neurons differentiated toward a GABAergic fate. This touch-induced neurogenesis reflected the novelty of the stimuli, its diversity, as well as stimulus duration. Introducing adult neurogenesis as a potential mechanism of response to a novel stimulus and for habituation to repeated sensory exposures opens up potential new directions in treating hypersensitivity, pain and other mechanosensory disorders.

PMID:
21079604
DOI:
10.1038/mp.2010.116
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center