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Nat Chem Biol. 2010 Dec;6(12):866-8. doi: 10.1038/nchembio.471.

Grand challenge commentary: The chemistry of a dynamic genome.

Author information

1
Division of Infectious Disease, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. rkohli@upenn.edu

Abstract

In the postsequencing era, chemical biology is uniquely situated to investigate genomic DNA alterations arising through epigenetic modifications, genetic rearrangements or active mutation. These transformations significantly expand nature's diversity and may profoundly alter our view of DNA's coding potential.

PMID:
21079591
DOI:
10.1038/nchembio.471
[Indexed for MEDLINE]

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