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Clin J Sport Med. 2010 Nov;20(6):464-8. doi: 10.1097/JSM.0b013e3181fc0a81.

Apolipoprotein E genotype and concussion in college athletes.

Author information

1
Department of Kinesiology, Temple University, Philadelphia, Pennsylvania, USA. rtierney@temple.edu

Abstract

OBJECTIVE:

To evaluate the association between apolipoprotein E (APOE) polymorphisms (E2, C/T Arg158Cys; E4, T/C Cys112Arg; and promoter, g-219t) and the history of concussion in college athletes. We hypothesized that carrying 1 or more APOE rare (or minor) allele assessed in this study would be associated with having a history of 1 or more concussions.

DESIGN:

Multicenter cross-sectional study.

SETTING:

University athletic facilities.

PARTICIPANTS:

One hundred ninety-six male football (n = 163) and female soccer (n = 33) college athletes volunteered.

INTERVENTIONS:

Written concussion history questionnaire and saliva samples for genotyping.

MAIN OUTCOME MEASURES:

Self-reported history of a documented concussion and rare APOE genotype (E2, E4, promoter).

RESULTS:

There was a significant association (Wald χ² = 3.82; P = 0.05; odds ratio = 9.8) between carrying all APOE rare alleles and the history of a previous concussion. There was also a significant association (Wald χ² = 3.96, P = 0.04, odds ratio = 8.4) between carrying the APOE promoter minor allele and experiencing 2 or more concussions.

CONCLUSIONS:

Carriers of all 3 APOE rare (or minor) alleles assessed in this study were nearly 10 times more likely to report a previous concussion and may be at a greater risk of concussion versus noncarriers. Promoter minor allele carriers were 8.4 times more likely to report multiple concussions and may be at a greater risk of multiple concussions versus noncarriers. Research involving larger samples of individuals with multiple concussions and carriers of multiple APOE rare alleles is warranted.

PMID:
21079443
DOI:
10.1097/JSM.0b013e3181fc0a81
[Indexed for MEDLINE]

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