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Genes Dev. 2010 Nov 15;24(22):2463-79. doi: 10.1101/gad.1971610.

The essence of senescence.

Author information

1
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Abstract

Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.

PMID:
21078816
PMCID:
PMC2975923
DOI:
10.1101/gad.1971610
[Indexed for MEDLINE]
Free PMC Article

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