Format

Send to

Choose Destination
Int J Cardiol. 2012 Mar 22;155(3):372-7. doi: 10.1016/j.ijcard.2010.10.053. Epub 2010 Nov 13.

Immune responses after acute ischemic stroke or myocardial infarction.

Author information

1
Department of Neurology, Charité University Medicine Berlin, Germany. georg.haeusler@charite.de

Abstract

BACKGROUND:

We recently demonstrated an immediate immunodepressive state after acute ischemic stroke in humans.

METHODS:

In the present study, we prospectively analyzed immune responses in patients with middle cerebral artery stroke (n=20), acute myocardial infarction (n=20) and healthy controls (n=20, also matched for age and gender).

RESULTS:

Compared to controls, a rapid depression of monocytic HLA-DR expression and a defective lymphocytic IFN-γ production was obvious after ischemic stroke or myocardial infarction, while total counts of leukocytes and monocytes were significantly higher after myocardial infarction. A T cell-mediated lymphopenia was accentuated in patients with severe stroke, obviously predisposing these patients for nosocomial infections.

CONCLUSIONS:

Our data reveal an immediate and to some extent differential suppression of cell-mediated immune responses after ischemic stroke or myocardial infarction respectively.

PMID:
21078527
DOI:
10.1016/j.ijcard.2010.10.053
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center