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Skin Therapy Lett. 2010 Nov-Dec;15(10):5-7.

Benzoyl peroxide: enhancing antibiotic efficacy in acne management.

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Division of Dermatology, University of Toronto, Women's College Hospital, Toronto, ON, Canada.


Benzoyl peroxide is one of the most widely used topical agents for acne. It has potent antibacterial and mild anti-inflammatory and comedolytic effects. To treat mild to moderate acne, it can be used alone or in combination with topical antibiotics and topical retinoids. The combination of benzoyl peroxide with either erythromycin or clindamycin is synergistic and well-tolerated. In more severe acne, when oral antibiotics are required, benzoyl peroxide can contribute to suppressing the emergence of resistant strains of Propionibacterium acnes.

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