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Mod Pathol. 2011 Feb;24(2):157-67. doi: 10.1038/modpathol.2010.200. Epub 2010 Nov 12.

Basal-like and triple-negative breast cancers: a critical review with an emphasis on the implications for pathologists and oncologists.

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1
Clarian Pathology Lab, Department of Pathology and Internal Medicine, Indiana University, Indianapolis, USA. sbadve@iupui.edu

Abstract

Breast cancer is a heterogeneous disease encompassing a variety of entities with distinct morphological features and clinical behaviors. Although morphology is often associated with the pattern of molecular aberrations in breast cancers, it is also clear that tumors of the same histological type show remarkably different clinical behavior. This is particularly true for 'basal-like cancer', which is an entity defined using gene expression analysis. The purpose of this article was to review the current state of knowledge of basal-like breast cancers, to discuss the relationship between basal-like and triple-negative breast cancers, and to clarify practical implications of these diagnoses for pathologists and oncologists.

PMID:
21076464
DOI:
10.1038/modpathol.2010.200
[Indexed for MEDLINE]
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