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Nat Struct Mol Biol. 2010 Dec;17(12):1492-4. doi: 10.1038/nsmb.1944. Epub 2010 Nov 14.

Crystal structure of a non-neutralizing antibody to the HIV-1 gp41 membrane-proximal external region.

Author information

1
Duke Human Vaccine Institute, Duke University School of Medicine, Durham, North Carolina, USA. nathan.nicely@duke.edu

Abstract

The monoclonal antibody 13H11 shares part of its epitope in the HIV-1 gp41 membrane-proximal external region (MPER) with the rare, broadly neutralizing human antibody 2F5. Although 13H11 partially cross-blocked 2F5 binding, 13H11 is non-neutralizing and does not block 2F5 neutralization. We show that unlike 2F5, 13H11 binds to a well-defined helical MPER structure that is consistent with the structure of gp41 in a post-fusion six-helix bundle conformation.

PMID:
21076400
PMCID:
PMC6081738
DOI:
10.1038/nsmb.1944
[Indexed for MEDLINE]
Free PMC Article

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