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Trends Biochem Sci. 1990 Jan;15(1):26-30.

Short chain diol metabolism in human disease states.

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Laboratory of Metabolism and Molecular Biology, National Institute on Alcoholism and Alcohol Abuse, Rockville, MD 20852.


Recent clinical studies have shown the presence of two short chain diols, meso-2,3-butanediol and D/L-2,3-butanediol, and in most cases 1,2-propanediol in either serum or urine collected from humans in several apparently unrelated disease states: congenital propionic and methylmalonic acidemia, premature infants, and alcoholics both in the presence and absence of ethanol. In addition 1,2-propanediol has been shown in patients during prolonged starvation, and in patients with diabetic keto-acidosis. No common defect is known to exist in these metabolic states. Understanding how these compounds are produced in clinically well-defined diseases such as methyl malonic and propionic aciduria, however, may help explain how and why these compounds are produced in alcoholics.

[Indexed for MEDLINE]

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