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Virology. 2011 Feb 5;410(1):7-16. doi: 10.1016/j.virol.2010.10.003. Epub 2010 Nov 13.

Sendai virus induced cytoplasmic actin remodeling correlates with efficient virus particle production.

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Department of Microbiology and Molecular Medicine, Faculty of Medicine University of Geneva, CMU, 1 rue Michel-Servet, 1211 Geneva 4, Switzerland.


Cytoplasmic actins have been found interacting with viral proteins and identified in virus particles. We analyzed by confocal microscopy the cytoplasmic β- and γ-actin patterns during the course of Sendai virus infections in polarized cells. We observed a spectacular remodeling of the β-cytoplasmic actin which correlated with productive viral multiplication. Conversely, suppression of M during the course of a productive infection resulted in the decrease of particle production and the absence of β-actin remodeling. As concomitant suppression of β- and γ-actins resulted as well in reduction of virus particle production, we propose that Sendai virus specifically induces actin remodeling in order to promote efficient virion production. Beta- and γ-cytoplasmic actin recruitment could substitute for that of the endosomal sorting complex required for transport (ESCRT) mobilized by other enveloped viruses but apparently not used by Sendai virus.

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