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Curr Opin Cell Biol. 2011 Feb;23(1):22-9. doi: 10.1016/j.ceb.2010.10.006. Epub 2010 Nov 11.

Receptor mobility, the cytoskeleton, and particle binding during phagocytosis.

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1
Cell Biology Program, Hospital for Sick Children, 555 University Ave., Toronto M5G 1X8, Canada.

Abstract

Particle engulfment during phagocytosis has long been appreciated to be an active, actin-driven process. By contrast, the preceding stage--securing the target to the surface of the phagocyte--was thought to result from the passive diffusion of receptors along the membrane towards their ligands on the particle surface. Recent evidence, however, challenges this notion, demonstrating that receptors do not diffuse freely along the phagocyte surface and that actin polymerization and tyrosine phosphorylation are required for optimal particle binding. The interpretation and significance of these observations are the subject of this opinion piece.

PMID:
21074980
DOI:
10.1016/j.ceb.2010.10.006
[Indexed for MEDLINE]
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