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FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.

Histone arginine methylation.

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1
The University of Texas MD Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957, United States.

Abstract

Arginine methylation is a common posttranslational modification (PTM). This type of PTM occurs on both nuclear and cytoplasmic proteins, and is particularly abundant on shuttling proteins. In this review, we will focus on one aspect of this PTM: the diverse roles that arginine methylation of the core histone tails play in regulating chromatin function. A family of nine protein arginine methyltransferases (PRMTs) catalyze methylation reactions, and a subset target histones. Importantly, arginine methylation of histone tails can promote or prevent the docking of key transcriptional effector molecules, thus playing a central role in the orchestration of the histone code.

PMID:
21074527
PMCID:
PMC3409563
DOI:
10.1016/j.febslet.2010.11.010
[Indexed for MEDLINE]
Free PMC Article
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