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Trends Cell Biol. 2011 Feb;21(2):74-80. doi: 10.1016/j.tcb.2010.10.004. Epub 2010 Nov 10.

Inactive yet indispensable: the tale of Jarid2.

Author information

1
Lymphocyte Development Group, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London, W12 0NN, UK.

Abstract

Methylation of histone tails is believed to be important for the establishment and inheritance of gene expression programs during development. Jarid2/Jumonji is the founding member of a family of chromatin modifiers with histone demethylase activity. Although Jarid2 contains amino acid substitutions that are thought to abolish its catalytic activity, it is essential for the development of multiple organs in mice. Recent studies have shown that Jarid2 is a component of the polycomb repressive complex 2 and is required for embryonic stem (ES) cell differentiation. Here, we discuss current literature on the function of Jarid2 and hypothesize that defects resulting from Jarid2 deficiency arise from a failure to correctly prime genes in ES cells that are required for later stages in development.

PMID:
21074441
PMCID:
PMC3034028
DOI:
10.1016/j.tcb.2010.10.004
[Indexed for MEDLINE]
Free PMC Article

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