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Cell. 2010 Nov 12;143(4):508-25. doi: 10.1016/j.cell.2010.10.008.

Pluripotency and cellular reprogramming: facts, hypotheses, unresolved issues.

Author information

1
The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. hanna@wi.mit.edu

Abstract

Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can interconvert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and epigenetic determinants that convert one cell type into another. Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions.

PMID:
21074044
PMCID:
PMC3032267
DOI:
10.1016/j.cell.2010.10.008
[Indexed for MEDLINE]
Free PMC Article

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