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Nature. 1990 Mar 15;344(6263):219-23.

Dependence of position-effect variegation in Drosophila on dose of a gene encoding an unusual zinc-finger protein.

Author information

1
Department of Genetics, Martin Luther University, Halle, DDR.

Abstract

Position-effect variegation is the inactivation in some cells of a gene translocated next to heterochromatin, the region of the chromosome that is permanently condensed. The number of copies of the Drosophila gene Suvar(3)7 is a dose-limiting factor in this phenomenon, and seems from its sequence that it encodes a protein with five widely spaced zinc-fingers. This novel arrangement of zinc-fingers could help in packaging the chromatin fibre into heterochromatin, and also reflect a novel method of controlling the expression from DNA domains.

PMID:
2107402
DOI:
10.1038/344219a0
[Indexed for MEDLINE]

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