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J Neurochem. 2011 Jan;116(2):164-76. doi: 10.1111/j.1471-4159.2010.07109.x.

The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.

Author information

1
The New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA. gmiller@hms.harvard.edu

Abstract

It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.

PMID:
21073468
PMCID:
PMC3005101
DOI:
10.1111/j.1471-4159.2010.07109.x
[Indexed for MEDLINE]
Free PMC Article
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