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Nucleic Acids Res. 2011 Jan;39(Database issue):D591-5. doi: 10.1093/nar/gkq1154. Epub 2010 Nov 11.

Effective--a database of predicted secreted bacterial proteins.

Author information

1
Department of Genome Oriented Bioinformatics, Wissenschaftszentrum Weihenstephan, Technische Universität München, Maximus-von-Imhof-Forum 3, 85354 Freising, Germany.

Abstract

Protein secretion is a key virulence mechanism of pathogenic and symbiotic bacteria, which makes the investigation of secreted proteins ('effectors') crucial for understanding the molecular bacterium-host interactions. Effective (http://effectors.org) is a database of predicted bacterial secreted proteins, implementing two complementary prediction strategies for protein secretion: the identification of eukaryotic-like protein domains and the recognition of signal peptides in amino acid sequences. The Effective web portal provides user-friendly tools for browsing and retrieving comprehensive precalculated predictions for whole bacterial genomes as well as for the interactive prediction of effectors in user-provided protein sequences.

PMID:
21071416
PMCID:
PMC3013723
DOI:
10.1093/nar/gkq1154
[Indexed for MEDLINE]
Free PMC Article

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