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Curr Opin Chem Biol. 2010 Dec;14(6):774-80. doi: 10.1016/j.cbpa.2010.09.013. Epub 2010 Nov 9.

Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications.

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1
Division of Chemistry and Chemical Engineering, Joseph J. Jacobs Institute for Molecular Engineering for Medicine, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

Residue-specific incorporation of non-canonical amino acids into proteins allows facile alteration and enhancement of protein properties. In this review, we describe recent technical developments and applications of residue-specific incorporation to problems ranging from elucidation of biochemical mechanisms to engineering of protein-based biomaterials. We hope to inform the reader of the ease and broad utility of residue-specific non-canonical amino acid incorporation with the goal of inspiring investigators outside the field to consider applying this tool to their own research.

PMID:
21071259
PMCID:
PMC3008400
DOI:
10.1016/j.cbpa.2010.09.013
[Indexed for MEDLINE]
Free PMC Article
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