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Acta Otolaryngol. 2011 Mar;131(3):247-57. doi: 10.3109/00016489.2010.524938. Epub 2010 Nov 11.

Noninvasive evaluation of endolymphatic space in healthy volunteers using magnetic resonance imaging.

Author information

1
Department of Otolaryngology, Beijing Hospital, Capital Medical University, China.

Abstract

CONCLUSIONS:

A new method for noninvasive standard evaluation of normal endolymphatic space and endolymphatic hydrops using magnetic resonance imaging (MRI) is indicated.

OBJECTIVE:

To standardize the evaluation of endolymphatic space in the cochlea and the vestibule in healthy volunteers by applying noninvasive intratympanic gadolinium (Gd) perfusion through the eustachian tube and three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI).

METHODS:

This was a prospective study. 3D-FLAIR MRI was performed with a 3 Tesla (3 T) unit 24 h after intratympanic administration of Gd through the eustachian tube in 20 healthy volunteers. Pure tone test and tympanometry were performed 24 h before Gd was administered, and 24 h and 1 month after Gd administration.

RESULTS:

Gd was present in the perilymph of the inner ear, which clearly displayed the endolymphatic space on 3D-FLAIR MRI with a visible borderline between the perilymph and the endolymph. In healthy volunteers, the normal value for the endolymphatic space in the cochlea ranged between 9% and 28%, and that in the vestibule was between 14% and 40%. No significant changes in pure tone test and tympanometry were noted.

PMID:
21070090
DOI:
10.3109/00016489.2010.524938
[Indexed for MEDLINE]

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