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Clin Chem. 2011 Feb;57(2):158-61. doi: 10.1373/clinchem.2010.148270. Epub 2010 Nov 10.

Is diabetes mellitus a continuous spectrum?

Author information

1
Department of Medicine, DVA Puget Sound Health Care System, Seattle, WA 98108, USA. bbrooks@u.washington.edu

Abstract

BACKGROUND:

Diabetes mellitus has been historically divided into type 1 and type 2 diabetes, with type 1 being an autoimmune disease and type 2 being primarily a metabolic disease.

CONTENT:

The current diabetes classification scheme needs to be reevaluated because of the accumulating evidence of immune system involvement in the pathophysiology of type 2 diabetes.

SUMMARY:

There are similarities and differences between type 1 and type 2 diabetes with regard to pathogenesis, pathophysiology, and genetics. We propose a resolution to the dilemma of the current classification scheme.

PMID:
21068340
DOI:
10.1373/clinchem.2010.148270
[Indexed for MEDLINE]
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