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J Neurosci. 2010 Nov 10;30(45):15030-3. doi: 10.1523/JNEUROSCI.3330-10.2010.

Assessing neuronal metabolism in vivo by modeling imaging measures.

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1
Department of Brain Repair and Rehabilitation, NMR Unit, UCL Institute of Neurology, London WC1N 3BG, United Kingdom. o.ciccarelli@ion.ucl.ac.uk

Abstract

Mitochondrial dysfunction contributes to the pathogenesis of many neurological diseases, including multiple sclerosis (MS), but is not directly measurable in vivo. We modeled N-acetyl-aspartate (NAA), which reflects axonal structural integrity and mitochondrial metabolism, with imaging measures of axonal structural integrity (axial diffusivity and cord cross-sectional area) to extract its mitochondrial metabolic contribution. Lower residual variance in NAA, reflecting reduced mitochondrial metabolism, was associated with greater clinical disability in MS, independent of structural damage.

PMID:
21068308
PMCID:
PMC3044872
DOI:
10.1523/JNEUROSCI.3330-10.2010
[Indexed for MEDLINE]
Free PMC Article
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