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J Clin Microbiol. 2011 Jan;49(1):423-5. doi: 10.1128/JCM.01836-10. Epub 2010 Nov 10.

Staphylococcal IgM enzyme-linked immunosorbent assay for diagnosis of periprosthetic joint infections.

Author information

1
Department of Public Health and Infectious Diseases, Sapienza University, P. le Aldo Moro 5, 00185 Rome, Italy.

Abstract

Delayed orthopedic joint prosthesis infections (DOJP-Is) due to staphylococci frequently result in prosthetic revision. Specific and noninvasive diagnostic tests are unavailable, and DOJP-Is are commonly diagnosed at advanced stages of disease. An enzyme-linked immunosorbent assay (ELISA) was developed to detect serum antibodies against staphylococcal slime polysaccharide antigens. Using a cutoff of 0.35 ELISA units, the test showed a specificity of 95.1% (95% confidence interval [CI], 85.4 to 98.7%) and a sensitivity of 89.7% (71.5 to 97.3%) on a sample of 90 individuals.

PMID:
21068292
PMCID:
PMC3020415
DOI:
10.1128/JCM.01836-10
[Indexed for MEDLINE]
Free PMC Article

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