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Bioinformatics. 2011 Jan 1;27(1):127-9. doi: 10.1093/bioinformatics/btq619. Epub 2010 Nov 8.

NBC: the Naive Bayes Classification tool webserver for taxonomic classification of metagenomic reads.

Author information

1
Department of Electrical and Computer Engineering, Drexel University, Philadelphia, PA, USA. gailr@ece.drexel.edu

Abstract

MOTIVATION:

Datasets from high-throughput sequencing technologies have yielded a vast amount of data about organisms in environmental samples. Yet, it is still a challenge to assess the exact organism content in these samples because the task of taxonomic classification is too computationally complex to annotate all reads in a dataset. An easy-to-use webserver is needed to process these reads. While many methods exist, only a few are publicly available on webservers, and out of those, most do not annotate all reads.

RESULTS:

We introduce a webserver that implements the naïve Bayes classifier (NBC) to classify all metagenomic reads to their best taxonomic match. Results indicate that NBC can assign next-generation sequencing reads to their taxonomic classification and can find significant populations of genera that other classifiers may miss.

AVAILABILITY:

Publicly available at: http://nbc.ece.drexel.edu.

PMID:
21062764
PMCID:
PMC3008645
DOI:
10.1093/bioinformatics/btq619
[Indexed for MEDLINE]
Free PMC Article

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