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J Drugs Dermatol. 2010 Nov;9(11):1347-52.

Photodynamic therapy with methylaminolevulinate 80 mg/g without occlusion improves acne vulgaris.

Author information

1
Innovaderm Research Inc., Montreal, Quebec, Canada. rbissonnette@innovaderm.ca

Abstract

BACKGROUND:

Photodynamic therapy (PDT) with methylaminolevulinate (MAL) under occlusion is effective for the treatment of acne vulgaris but is associated with significant phototoxic side effects.

OBJECTIVE:

To evaluate the safety and efficacy of topical MAL with or without occlusion followed by red light exposure in patients with facial acne vulgaris.

PATIENTS/METHODS:

Forty-four patients with facial acne vulgaris were randomized to receive four MAL applications (80 mg/g) at two-week intervals with occlusion on either the right or left side followed 90 minutes later by either 25 or 37 J/cm2 of red light.

RESULTS:

At 18 weeks after the first MAL-PDT treatment, the percentage of inflammatory lesions was reduced by a median of 31.7, 59.4, 58.1 and 55.8 percent for patients randomized to 25 J/cm2 without occlusion, 25 J/cm2 with occlusion, 37 J/cm2 without occlusion and 37 J/cm2 with occlusion respectively. MAL-PDT was, in general, well tolerated and only two patients discontinued their participation due to adverse events.

CONCLUSION:

PDT with MAL at 80 mg/g without occlusion reduces the number of inflammatory lesions in patients with facial acne vulgaris.

PMID:
21061756
[Indexed for MEDLINE]

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